The NOTCH3 Conjugated Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to notch receptor 2, notch receptor 3, notch receptor 3 (NOTCH3), and NOTCH2. This antibody recognizes Human antigen. The NOTCH3 Conjugated Antibody has been validated for the following applications: Other.
Description
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)